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KMID : 1234920080080010033
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Journal of Korean Oriental Association for Study of Obesity
2008 Volume.8 No. 1 p.33 ~ p.49
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The Inhibitory Effects of Sansayukbokhap-bang(SSYBHB) on the Obese-Mouse Induced High Fat Diet
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Kim Hyoung-Jun
Hong Seo-Young
Heo Dong-Seok
Oh Min-Seok
Yoon Il-Ji
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Abstract
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Objectives: In order to investigate the effects of Sansayukbokhap-bang (SSYBHB) on the hematological and histological changes.
Methods: C57BL/6 mice were fed with high fat diet. C57BL/6 mice were divided into four groups and fed for 15weeks.
Results: 1. The body weight of SSYBHB intake mice was significantly lower than high fat diet group. 2. The final increase of body weight was decreased significantly. 3. The levels of ALT, AST, total cholesterol, LDL-Cholesterol, triglyceride, Leptin were decreased significantly. 4. The levels of creatinine were decreased but did not show significance. 5. The level of HDL-cholesterol and the expression of β3AR mRNA gene in 3T3-L1 Adipocytes were increased significantly. 6. Adipocytes’ size was decreased significantly. 7. The expression of β3AR mRNA gene, Leptin mRNA gene and serotinin mRNA gene in Adipocytes tissue was decreased significantly.
Conclusion: Based on these results, it is proved that SSYBHB is effective on the therapy of obesity by referring to obese-gene and obese inhibitory. So, it is espected that the clinical application of SSYBHB can help the treatment of obesity.
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KEYWORD
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Sansayukbokhap-bang, obesity, C57BL/6mice, body weight
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